The Antisickling Properties of Aristeus Antennatus Extracts in the Management of Sickle Cell Disease

The antisickling effect of dried Aristeus antennatus was investigated to ascertain the efficacy extract sample inhibit polymerization sickle cell haemoglobin (HbSS), and improve Fe2+/Fe3+ ratio blood. first dried, ground into powder soaked in chloroform defat it order produce fat soluble fraction (filtrate). defatted residue air-dried later methanol for 24 hours obtain fraction. fractions (FAS) (MAS) were able HbSS varying degrees from 58% FAS 69% MAS. Phytochemical analysis revealed presence proanthocyanin, quinine, saponin, isoflavone, spartein, phytate, cyanogenic glycoside, catechin, flavone, tannin, oxalate, alkaloids others, at concentrations. Amino acid composition determined using amino analyzer (PTH), which a preponderance both essential non-essential acids some identified include: Phenylalanine, Histidine, Leucine, Lysine, Tryptophan, Isoleucine, Valine, Methionine, Proline, Arginine, Tyrosine, Serine others. However, MAS improved significantly. extracts with micro macro nutrients, vitamins, antioxidants, may be very beneficial management disease.